Scientist, Laboratory of Precision Disease Therapeutics (GIS)

Position Overview

The Laboratory of Precision Disease Therapeutics focuses on therapeutic target discovery and translational development for metabolic dysfunction-associated steatotic hepatitis (MASH), with a strong emphasis on siRNA-based therapeutics.

Our research integrates patient-derived multi-omics datasets with in vivo functional genetic screening and human in vitro disease models to systematically identify and validate clinically relevant therapeutic targets.

We are seeking a highly motivated Postdoctoral Fellow to lead and contribute to projects involving therapeutic target validation, disease modeling, and translational therapeutic development.

The successful candidate will work in a highly interdisciplinary and translational research environment and is expected to contribute scientifically through experimental design, data interpretation, troubleshooting, and project development.

Requirements

• Design and execute independent research projects related to MASH and siRNA therapeutics

• Perform molecular and cellular biology experiments, including gene perturbation studies and disease modeling

• Contribute to in vivo studies and functional validation experiments

• Analyze and interpret experimental data and present findings in internal and external meetings

• Participate in manuscript preparation, grant applications, and collaborative projects

• Contribute to scientific discussions, troubleshooting, and project strategy development

• Mentor junior lab members when appropriate

Requirements

• PhD degree in Biomedical Sciences, Molecular Biology, Pharmacology, or related fields

• Strong background in molecular biology, cell biology, or translational disease research

• Experience with mammalian primary cell culture and molecular techniques

• Ability to independently plan and execute experiments

• Strong scientific reasoning, communication, and problem-solving skills

• Ability to work collaboratively in a fast-paced research environment

Preferred Qualifications (Not Required but Advantageous)

• Experience in liver disease, metabolic disease, or fibrosis research

• Experience with siRNA or gene knockdown approaches

• Experience with in vivo mouse studies

• Familiarity with histology or imaging-based assays

• Experience working in translational or interdisciplinary research settings

• Publication record in relevant research areas

Interested candidates are invited to send a cover letter stating your research interests and experience, curriculum vitae, and the names and email addresses of three references to:

LEE Yong-An (Lee_Yong-An@a-star.edu.sg)